Cyber-physical systems (CPS) have become omnipresent in many areas of modern life, e.g. in the areas of automotive engineering, power grid development or healthcare. In recent years, CPS have changed from purely embedded system to complex networked systems that integrate hardware and software systems in an interdisciplinary environment. The high degree of dynamic coupling in such systems makes the design, development and optimization of CPS a challenging task. Over the past 15 years, we have worked closely with different partners from industry and science to develop CPS with a high level of design maturity. We provide M&SBSE consultation services and software as well as custom models, simulations and custom software features to our national and international CPS customers.